Otrivin Dual Relief: Xylometazoline and ipratropium

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Woman sinus pain

Treats the worst nasal symptoms all at once1–4

Otrivin Dual Relief provides symptomatic treatment of the worst nasal symptoms, such as blocked nose, rhinorrhoea, sinus pressure and sneezing due to common colds and acute phases of allergic rhinitis.1–4

Woman smelling flowers

Immediate and long-lasting relief of nasal cold symptoms

Otrivin Dual Relief nasal spray is recommended for active, busy individuals who need immediate and long-lasting relief from the full range of nasal cold symptoms.1-4

Xylometazoline-hydrochlorides

Xylometazoline and ipratropium: Effective combination

A combination of two topical agents, to relieve patients’ worst cold symptoms at once:

Xylometazoline hydrochloride (0.05%):

  • A sympathomimetic agent, provides rapid and long-lasting relief (within 5-10 minutes and for up to 6-8 hours) of nasal congestion3-5
  • It improves nasal airflow, reduces mucus hypersecretions3 and relieves sinus pressure6-9

Ipratropium bromide (0.06%):

  • An anticholinergic agent that reduces watery discharge from nasal mucosa (rhinorrhoea) and lessens sneezing2,4,10,11

Recommend Otrivin Dual Relief to your patients for immediate and long-lasting relief from the full range of nasal cold symptoms

Otrivin Dual Releif packshot

Otrivin Dual Relief (Xylometazoline hydrochloride 0.05%+ ipratropium bromide 0.06%)

For patients who are looking for rapid and effective relief of nasal cold symptoms.1-4

Otrivin Dual Relief product details

  • Nasal spray solution Each 1ml contains:

    0.5 mg Xylometazoline hydrochloride and 0.6 mg Ipratropium bromide For Nasal Administration ONLY.

    Read all of this leaflet carefully before you start using this medicine because it contains important information for you.

    • Keep this leaflet. You may need to read it again.
    • Ask your pharmacist if you need more information or advice.
    • You must contact a doctor if your symptoms worsen or do not improve.
    • If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your doctor or pharmacist.

  • The recommended dose is:

    Adults(18+): One puff in each nostril as needed, up to 3 times daily for maximum 7 days. Leave at least 6 hours between two doses. Do not exceed 3 applications daily into each nostril. You should not use Otrivin Dual Relief longer than 7 days as chronic treatment with nasal decongestants such as Xylometazoline (one of the active substances in Otrivin Dual Relief) may cause swelling of the nasal mucosa (so called rhinitis medicamentosa).

    1. Always blow your nose before using the nasal spray.
    2. Remove the dust cap.
    3. Do not cut the nozzle. The metered dose spray is ready to prime before use.
    4. Before the first application, prime the pump by actuating 4 times.
    5. Once primed, the pump will normally remain charged throughout regular daily treatment periods. Should the spray not be ejected during the full actuation stroke, or if the product has not been used for longer than 6 days, the pump will need to be reprimed with 4 actuations as initially performed.
    6. Hold the bottle upright. Bend your head slightly forward.
    7. Close one nostril by placing your finger against the side of your nose and insert the spray lip into the other nostril. Press the pump quickly while inhaling through the nose.
    8. Repeat this procedure in the other nostril.
    9. The effect occurs within 5-15 minutes. Avoid spraying Otrivin Dual Relief in or around the eyes. Ask your doctor or pharmacist for advice if you are unsure.

  • Talk to your doctor or pharmacist before using Otrivin Dual Relief.

    Otrivin Dual Relief must be administered with caution to patients with:

    • Hypertension, cardiovascular diseases
    • Hyperthyroidism, diabetes mellitus
    • Hypertrophy of the prostate, stenosis of the bladder bar
    • Pheochromocytoma

    Caution is recommended in patients predisposed to:

    • Angle closure glaucoma
    • Epistaxis (e.g. elderly)
    • Paralytic ileus
    • Cystic fibrosis

    Immediate hypersensitivity including urticaria, angioedema, rash, bronchospasm, pharyngeal oedema and anaphylaxis may occur. These symptoms may appear individually or all combined as a severe allergic reaction. If this occurs, immediately STOP using Otrivin Dual Relief. The medicinal product must be used with caution in patients who are sensitive to adrenergic substances, which may give symptoms such as sleeping disturbances, dizziness, tremor, cardiac arrythmias or elevated blood pressure.

    The treatment duration should not exceed 7 days, as chronic treatment with xylometazoline hydrochloride may cause swelling of the nasal mucosa and hypersecretion because of increased sensibility in the cells, ”rebound effect” (rhinitis medicamentosa). Patients should be instructed to avoid spraying Otrivin Dual Relief in or around the eye. If Otrivin Dual Relief gets in contact with the eyes, the following may occur: temporary blurred vision, irritation, pain, red eyes. Aggravation of angle closure glaucoma may also develop. The patient should be instructed to rinse their eyes with cold water if Otrivin Dual Relief gets in direct contact with the eyes and to contact a doctor if they experience pain in the eyes or blurred vision.

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Otrivin Dual Relief: Immediate and long-lasting relief of nasal cold symptoms1-4

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