Panadol overview

The world’s leading range for the treatment of symptoms of cold and flu

The Panadol Cold & Flu range contains clinically proven active ingredients to fight multiple symptoms*

* Align with LOC SmPC

Panadol – relief from cold and flu symptoms^1-10

Cold symptoms relief

Panadol products relieve the eight most bothersome symptoms of colds and flu:fever, sinus congestion, headache, muscle pain, body pain, nasal congestion, sinus pain, and sore throat pain.^1-10

Effective combination

Panadol products are powerful, multi-action, convenient, and well tolerated combinations that are suitable for active, busy patients, who need to stay alert.^1-10

Strong scientific evidence

Multiple clinical studies, published in international, peer-reviewed journals, showed the strength of Panadol products for relieving cold and flu symptoms.^3,5-10

Panadol – in-depth patient understanding

Cold symptoms are common and bothersome

Control the most bothersome and frequent symptoms of colds and flu

Cold and flu symptoms are frequent and bothersome. These symptoms include: fever (elevated body temperature), nasal congestion (a blocked nose), rhinorrhoea (a runny nose), sinus pressure and pain (headaches), sneezing (blowing your nose often), sore throat (pain in the pharynx), and body aches (pain all over the body). The Panadol range offers various options of clinically proven products, to relieve these symptoms.^1-10

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Prevalence of the condition

Are your patients experiencing cold and flu symptoms?

Between 5-10% of adults worldwide get a cold/flu every year.¹¹

On average, adults get 4 to 6 colds per year, while children get 6 to 8 of them.¹²
Patients’ daily lives are impacted by cold and flu symptoms

Cold and flu symptoms can have a major impact:

Impact on daily life

52% of people stated that a cough/cold had a significant effect on their daily life.¹³

Reduced productivity

People reported a productivity decrease of 26%.¹³

Decreased work/school attendance

Nearly 50% of people reported missing work or school for 1-2 days.¹³

Disturbed/poor sleep

Total sleep time decreased by an average of 23 minutes.¹⁴

Performance reduction

Reduced performance, mood, reaction time, and cognitive performance, was reported.^13,15-17

The Panadol range is specially formulated for clinically proven relief from the symptoms of colds and flu^1-10

Paracetamol

Paracetamol is an over-the-counter drug used for pain relief and fever. It provides effective and sustained fever control, which starts to relieve fever in 30 minutes for up to 6 hours.³

Pseudoephedrine is a sympathomimetic drug that acts on the adrenergic receptors and causes vasoconstriction of the muscles lining the walls of small blood vessels in the nasal mucosa. By contracting the blood vessels, pseudoephedrine increases the patency of the airways and causes a decrease in the symptoms of nasal congestion.^5,18

Phenylephrine hydrochloride

Phenylephrine is a sympathomimetic decongestant that has a potent vasoconstrictive effect on the capillaries in the nasal lining, which in turn leads to a reduction in the swelling of the nasal mucosa, thereby reducing congestion.⁶

Chlorpheniramine

Chlorpheniramine is a first-generation antihistamine used to relieve a runny nose and sneezing symptoms, to help patients sleep restfully.¹⁹

Guaifenesin

Guaifenesin is an expectorant that is suitable for the treatment of a wet cough, and is available in combination with paracetamol and phenylephrine, for short-term relief of the symptoms of colds and influenza.^20-22

Caffeine

Caffeine is an analgesic adjuvant for paracetamol that increases mental alertness and improves wakefulness.^23-25

Ascorbic acid

Ascorbic acid (Vitamin C) is an essential component of the human diet. It is included to supplement dietary intake of Vitamin C. This is particularly valuable in the early stages of acute viral infections, e.g., the common cold, as Vitamin C reserves may be low at this time and the appetite poor.²⁶

Butamirate

Butamirate acts centrally to suppress coughs.²⁸It also has a non-specific anticholinergic effect, and a bronchospasmolytic effect that relieves sudden muscle constriction in the walls of the bronchioles. Together, these facilitate respiratory function.^28-30

The Panadol range offers clinically proven solutions tailored to individual patient needs^1–10

Panadol C&F Vapour Release

Panadol C&F Hot Liquid works as a soothing hot remedy for prompt relief from the symptoms of colds and flu, including headache, nasal congestion, sinus congestion, sinus pain, body aches, and fever.^{3,6,7,9,19,31,32}

^{Key ingredients: Paracetamol 600mg, phenylephrine hydrochloride 10mg, and ascorbic acid 40mg.}

Panadol C&F Day

Panadol C&F Day provides powerful and effective relief against cold and flu symptoms, with caffeine to produce a synergistic effect with paracetamol.^{3,4,6,8-10,18-20,33-40}

^{Key ingredients:Paracetamol 50mg, phenylephrine 5mg, and caffeine 25mg.}

Panadol C&F Night

Panadol C&F Night/Nasal is designed to relieve fever, aches, and the pains associated with colds and flu, which cause difficulty in getting to sleep.^{4,6,19,27,34-36}

^{Key ingredients: Paracetamol 500mg, pseudoephedrine hydrochloride 30mg, and chlorphenamine maleate 2mg.}

Panadol C&F All in One

Panadol C&F All in One provides fast and effective relief against multiple cold symptoms such as: chesty cough, nasal congestion, fever, body aches, headache, sore throat.^{3,6-8,20,21,32,35}

^{Key ingredients: Paracetamol 250mg, phenylephrine hydrochloride 5mg, and guaifenesin 100mg.}

PanaNatural Cough Syrup

PanaNatural cough syrup–Trusted Formulation for Relief of Dry and Productive Cough

100 % natural ingredients including : honey, marshmallow Ribwort plantain, and agrimony

The Panadol range – the world’s leading cold and flu products

Colds

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Patient resources

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References

Centers for Disease Control and Prevention. 2018. Cold Versus Flu. Available at: https://www.cdc.gov/flu/about/qa/coldflu.htm (Accessed March 2020).
Eccles R et al. Open J Resp Dis 2014; 4:73–8230.
Bachert C et al. Clin Ther 2005; 27:993–1003.
Eccles R. J Clin Pharm Ther 2006; 31:309-319.
Horak F et al. Ann Allergy Asthma Immunol 2009; 102:116–120.
Kollar C et al. Clin Ther 2007; 29:1057-1070.
Cohen BM. Eur J Clin Pharmacol 1972; 5:81–86.
Schachtel BP et al. Clin Pharmacol Ther 1988; 44:704–711.
D’Agostino RB et al. Clin Pharmacol Ther 1998; 64:579–596.
Derry CJ et al. Cochrane Database Syst Rev 2014; 12:CD009281.
National Advisory Committee on Immunization. Canadian Immunization Guide Chapter on Influenza and Statement on Seasonal Influenza Vaccine for 2017–2018.
Worrall G. Can Fam Physician 2011; 57:1289–1290.
Dicpinigaitis PV et al. Curr Med Res Opin 2015; 31:1519–1525.
Drake CL et al. Physiol Behav 2000; 71:75–81.
Smith AP. Psychoneuroendocrinology 2013; 38:744–751.
Thomas M et al. Ergonomics 2000; 43:1342–1349.
Smith A et al. Psychoneuroendocrinology 1998; 23:733–739.
Eccles R. Lancet Infect Dis 2005; 5:718–725.
Doyle WJ et al. Pediatr Infect Dis J 1988; 7:229–238.
Brayfield A. Martindale: The Complete Drug Reference. 38 ed. London: Pharmaceutical Press; 2014.
Robinson RE et al. Curr Ther Res Clin Exp 1977; 22:284–296.
Seagrave J et al. Exp Lung Res 2011; 37:606-614.
Iqbal N et al. Biopharm Drug Dispos 1995; 16:481-487.
Laska EM et al. JAMA 1984; 251:1711–1718.
Shapiro RE. Neurol Sci 2007; 28:S179–S183.
Paracetamol-Pseudoephedrine-Ascorbic Acid GDS_v 10.0_CLEAN March 2017
Hemila H et al. Cochrane Database Syst Rev 2013; 3:CD000980.
Płusa T. Pol Merkur Lekarski 2017; 43:69–74.
Charpin J et al. Respiration 1990; 57:275–279.
Lejeune J et al. Rev Med Suisse Romande 1990; 110:181–185.
Roth RP et al. Ann Oto Rhino Laryngol 1977; 86:235-242.
Sanu A et al. Rhinology 2008; 6:271-275.
Blaiss MS et al. Curr Med Res Opin 2015; 31:1527–1538.
Brunton L et al. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 12 ed. New York, NY: McGraw-Hill Medical; 2011.
Burnett I et al. Clin Ther 2006; 28:1273–1278.
Chua SS et al. Biopharm Drug Dispos 1989; 10:1–14.
Empey DW et al. Drugs 1981; 21:438–443.
Peters BH et al. Am J Med 1983; 74:36–42.
Prescott LF. Am J Ther 2000; 7:143–147.
Whelton A. Am J Ther 2005; 12:43–45.

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Panadol overview

The world’s leading range for the treatment of symptoms of cold and flu

Panadol – relief from cold and flu symptoms1-10

Cold symptoms relief

Effective combination

Strong scientific evidence

Panadol – in-depth patient understanding

Control the most bothersome and frequent symptoms of colds and flu

Are your patients experiencing cold and flu symptoms?

Cold and flu symptoms can have a major impact:

Impact on daily life

Reduced productivity

Decreased work/school attendance

Disturbed/poor sleep

Performance reduction

The Panadol range is specially formulated for clinically proven relief from the symptoms of colds and flu1-10

The Panadol range offers clinically proven solutions tailored to individual patient needs1–10