Butamirate formulations

Molecule
Women and child

Butamirate suppresses the cough reflex through a central effect1

Butamirate is a non-opioid cough suppressant, thought to act via a central effect. However, the exact mechanism of action is unknown.

It also possesses non-specific anticholinergic and bronchospasmolytic effects to facilitate respiratory function.1

Butamirate offers proven efficacy at reducing a dry cough2

  • Significant

    Reduced daytime and night-time cough severity (p<0.001)3

    Compared to baseline with data from a randomised, double-blind study evaluating butamirate citrate syrup and clobutinol syrup in adults (n=60) aged 18-81 years with cough.3

    Study summary

    5-6 hours

    The efficacy of butamirate is well demonstrated in various studies

    Butamirate starts to work in 5 minutes to 10 minutes and lasts up to 6 hours.1

    50%

    Relief in the first week of treatment2

    Data from a randomised, double-blind study evaluating butamirate citrate dragees and hydrocodone dragees in adults and children (n=100) aged 6-80 years with cough.

    Cough attacks were determined and summarised weekly, based on a point system.2

    Study summary

  • Child icon

    A study has shown that coughs are significantly reduced in children with the use of butamirate, which has good efficacy, and no adverse events were noted in children aged 6 weeks* to 10 years.

    Butamirate was associated with reducing cough duration in children.4

    * In GSK`s butamirate portfolio, butamirate oral drops solution 0.5% is indicated for children from 2 months old, however can only be used upon a doctors prescription in children below 2 years of age.

    Study summary

  • Samples icon

    Butamirate formulations should not be taken beyond 7 days duration without medical advice.

    Oral drops solution 0.5% for paediatric use

    • Children under 2 years of age: Only with a doctor’s prescription
    • Children 2 months to 1-year-old: 10 drops (2.5 mg) 4 times daily. Maximum daily dose: 40 drops (10 mg)
    • Children 1 to 3 years of age: 15 drops (3.75 mg) 4 times daily. Maximum daily dose: 60 drops (15 mg)
    • Over 3 years 25 drops (6.25 mg) 4 times daily. Maximum daily dose: 100 drops (25 mg)

    Syrup 0.15% with graduated measuring cup

    • Children 3 to 6 years of age: 5 mL (7.5 mg) 3 times daily. Maximum daily dose: 15 mL (22.5 mg)
    • Children 6 to 12 years of age: 10 mL (15 mg) 3 times daily. Maximum daily dose: 30 mL (45 mg)
    • Adolescents over 12years of age: 15 mL (22.5 mg) 3 times daily. Maximum daily dose: 45 mL (67.5 mg)
    • Adults: 15 mL (22.5 mg) 4 times daily. Maximum daily dose: 60 mL (90 mg)

    Tablets 50 mg

    • Adolescents over 12 years of age: 1 tablet (50 mg) 2 times daily. Maximum daily dose: 2 tablets (100 mg)
    • Adults: 1 tablet (50 mg) 3 times daily. Maximum daily dose: 3tablets (150 mg)

    Contradictions

    Do not take Sinecod if:

    • You are allergic to butamirate citrate or any of the other ingredients.

    Warnings and precautions

    • Do not use with other expectorant medicines.
    • If your symptoms persist or do not improve, speak to a doctor.1

  • Pill icon

    Adverse effects have rarely been reported with the use of butamirate, but may include somnolence, diarrhoea, nausea, and urticaria.1

Corsodyl chlorhexidine digluconate mouthwash

Sinecod packshot

Sinecod

Sinecod oral drops, syrup, tablets, and lozenges are formulated with butamirate for relief from a dry cough.

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